Vitamin-D Deficiency As a Potential Environmental Risk Factor in Multiple Sclerosis, Schizophrenia, and Autism
Kočovská E, Gaughran F, Krivoy A, Meier UC (2017) Front Psychiatry. 2017 Mar 27;8:47. doi: 10.3389/fpsyt.2017.00047. eCollection 2017
Abstract:
In this short review, we want to summarize the current findings on the role of vitamin-D in multiple sclerosis (MS), schizophrenia, and autism. Many studies have highlighted hypovitaminosis-D as a potential environmental risk factor for a variety of conditions such as MS, asthma, cardiovascular disease, and, more recently, psychiatric diseases.However, whether hypovitaminosis-D is a potential causative factor for the development or activity in these conditions or whether hypovitaminosis-D may be due to increased vitamin-D consumption by an activated immune system (reverse causation) is the focus of intense research.
Here, we will discuss current evidence exploring the role of vitamin-D in MS, schizophrenia, and autism and its impact on adaptive and innate immunity, antimicrobial defense, the microbiome, neuroinflammation, behavior, and neurogenesis.
More work is needed to gain insight into its role in the underlying pathophysiology of these conditions as it may offer attractive means of intervention and prevention.
FAB RESEARCH COMMENT:
See also:- Vuillermot et al 2017 - Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation
- Saad et al 2016 - Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder
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