Fructose and metabolic diseases: too much to be good
Shi, Y-N; Liu, Y-Jin; Xie, Z; Zhang, WJ. (2021) Chinese Medical Journal 134(11) 1276-1285 doi: 10.1097/CM9.0000000000001545
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Abstract:
Excessive consumption of fructose, the sweetest of all naturally occurring carbohydrates, has been linked to worldwide epidemics of metabolic diseases in humans, and it is considered an independent risk factor for cardiovascular diseases.We provide an overview about the features of fructose metabolism, as well as potential mechanisms by which excessive fructose intake is associated with the pathogenesis of metabolic diseases both in humans and rodents.
To accomplish this aim, we focus on illuminating the cellular and molecular mechanisms of fructose metabolism as well as its signaling effects on metabolic and cardiovascular homeostasis in health and disease, highlighting the role of carbohydrate-responsive element-binding protein in regulating fructose metabolism.
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For an accessible summary of this review, see the related news article:And for more information on sugar, see:
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