Inhibition of endometrial cancer by n-3 polyunsaturated fatty acids (PUFAs) in preclinical models
Zheng H, Tang H, Liu M, He M, Lai P, Dong H, Lin J, Jia C, Zhong M, Dai Y, Bai X, Wang L. (2014) Cancer Prev Res (Phila) pii: canprevres.0378.2013
Abstract:
Although preclinical and epidemiological studies have shown the importance of n-3 polyunsaturated fatty acids (PUFAs) in the prevention of hormone-responsive cancers such as breast cancer, evidence of the association between n-3 PUFAs and endometrial cancer risk is limited and no previous study has examined the effect of n-3 PUFAs on endometrial cancer in cellular and animal models. In this study, we demonstrated that docosahexenoic acid (DHA) dose-and time-dependently inhibited endometrial cancer cell proliferation, colony formation and migration, and promoted apoptosis. Dietary n-3 PUFAs efficiently prevented endometrial cancer cell growth in xenograft models. Moreover, ectopic expression of fat-1, a desaturase, catalyzed the conversion of n-6 to n-3 PUFAs and produced n-3 PUFAs endogenously, also suppressed endometrial tumor cell growth and migration, and potentiated apoptosis in endometrial cancer cell lines.FAB RESEARCH COMMENT:
Find the related newsitem here: 20 June 2014 - foodconsumer - Omega 3 fatty acids prevent endometrial cancer
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