Omega-3 benefits may be sustained in early psychosis
The positive effects of omega-3 supplementation seen in patients at high risk of psychosis in a previous randomised, controlled trial may be sustained, the investigators reported at the International Early Psychosis Conference in Tokyo, Japan.
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FAB RESEARCH COMMENT:
This study reports on the long-term follow-up (after almost 7 years) of participants in a pioneering randomised controlled treatment trial of dietary supplementation with the long-chain omega-3 from fish oils (EPA and DHA) for the prevention of psychosis.Results of the original study involving these young people - all of whom were originally judged to be at very high risk for developing full psychosis - showed striking reductions in the rate of transition to psychosis at 12-month follow-up for those who received omega-3 supplementation for just 3 months, compared with placebo treatment.
For details of the original study, see:
For details of this follow-up report, see:
When followed up a median of 6.7 years after the original intervention, just four (9.8%) of 41 patients in the omega-3 group had transitioned to psychosis, compared with 16 (40.0%) of 40 patients given placebo.
However, lead researcher G Paul Amminger (University of Melbourne, Victoria, Australia) cautioned that “it will not be possible to make recommendations on the efficacy of omega-3 preventing transition to psychosis until the results have been confirmed in two replication trials.”
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