Meta-analysis of All-Cause Mortality According to Serum 25-Hydroxyvitamin D
Garland CF, Kim JJ, Mohr SB, Gorham ED, Grant WB, Giovannucci EL, Baggerly L, Hofflich H, Ramsdell JW, Zeng K, Heaney RP. (2014) Am J Public Health
Web URL: Read more and related abstracts on the PubMed website
Abstract:
We examined the relationship between serum 25-hydroxyvitamin D (25[OH]D) and all-cause mortality.We searched biomedical databases for articles that assessed 2 or more categories of 25(OH)D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooled the data.
The hazard ratio for all-cause mortality comparing the lowest (0-9 nanograms per milliliter [ng/mL]) to the highest (> 30 ng/mL) category of 25(OH)D was 1.9 (95% confidence interval = 1.6, 2.2; P < .001).
Serum 25(OH)D concentrations less than or equal to 30 ng/mL were associated with higher all-cause mortality than concentrations greater than 30 ng/mL (P < .01).
Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL.
FAB RESEARCH COMMENT:
The related news item on Vit D can be found here:For more information on Vitamin D, please see the following article lists
(NB further lists on specific conditions can be found from FAB comments on many articles in these lists)
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